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Proteins and Peptides

Pig FcRn (FCGRT-B2M) heterodimer protein

Product Sizes
250 ug
£750.00
PIFCRN-U-250UG
5 x 250 ug
£3000.00
PIFCRN-U-5X250UG
About this Product
SKU:
PIFCRN-U
Additional Names:
FcRn, FCGRT, FCGRT & B2M, FCGRT and B2M, Neonatal Fc receptor, Neonatal receptor, Brambell receptor
Application:
Assay Development, ELISA, Immunoassay, Surface Plasmon Resonance
Extra Details:
IgG Fc fragment receptor transporter, also known as the neonatal Fc receptor or more commonly FcRn, consist of two subunits (FCGRT and B2M) and forms an MHC class I-like heterodimer. FcRn binds to the Fc domain of monomeric IgG and mediates the pH dependent recycling of IgG as well as its uptake from milk and transfer from mother to fetus.
Shipping Conditions:
Ambient
Storage Conditions:
Lyophilized proteins are stable at ambient temperature for at least 2 weeks. If the protein is not to be used immediately then the protein should be stored in lyophilized form at -20 °C for up 12 months. Once the protein has been reconstituted we recommend storage at 4 °C for up to one week. For longer term storage of protein in solution we recommend aliquoting into smaller vials to avoid repeated freeze-thaw cycles and storage at -20 or -80 °C for up to 3 months. To avoid surface adsorption loss and inactivation we strongly recommend that the protein should not be aliquoted in less than 10 μg per vial.
Supplier:
Gamma Proteins
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Pig FcRn on Coomassie Blue stained SDS-PAGE under non-reducing (NR) and reducing (R) conditions. The upper band is the FCGRT 'heavy' chain and the lower band is the B2M 'light' chain. The purity of the protein is greater than 95%.
Assessment of protein purity for pig FcRn by SEC-HPLC. The protein is greater than 95% pure.
Assessment of binding of pig FcRn, immobilized on a CM5 chip via an anti-His antibody, to a human IgG1 Fc fusion protein using a Biacore 8K instrument. The protein binds with an affinity constant (KD) of 345 nM.