JNJ-3792165
Product Sizes
5 mg
£168.00
10-5863-5MG
25 mg
£320.00
10-5863-25MG
About this Product
- SKU:
- 10-5863
- CAS Number:
- 353504-63-9
- Extra Details:
- JNJ-3792165 is a potent and selective antagonist at GPR139, a non-canonical opioid receptor. It has high affinity for human GPR139 (pKi = 7.7, displacement of [3H] JNJ-6353054) and behaves as an antagonist in a [35S]GTPG GammaS assay (pKb = 7.4) and calcium mobilization assay.1 It displayed no significant affinity in a selectivity screen of over 50 other neurotransmitter and neuropeptide receptors (less than 50% inhibition at 1 uM).1 Completely blocks (10 mM) the effects of optogenetic stimulation of dynorphin release in dynorphinergic neurons of the nucleus accumbens at 10 mM.2 JNJ-3792165 is an important new tool for exploring the biology of GPR139.3,4
- Immunogen:
- GPCR
- Molecular Weight:
- 374.27
- Physical State:
- Solid
- Purity:
- 98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
