SBI-797812
Product Sizes
5 mg
£168.00
10-5778-5MG
25 mg
£320.00
10-5778-25MG
About this Product
- SKU:
- 10-5778
- CAS Number:
- 2237268-08-3
- Extra Details:
- NAMPT is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) salvage pathway that converts nicotinamide to nicotinamide mononucleotide (NMN) which is responsible for most of the NAD+ formation in mammals.1 Cellular levels of NAD+ have been shown to decrease with age and NAMPT is believed to be a key enzyme in the aging/senescence process.2 SBI-797812 is a NAMPT activator, turning it into a "super catalyst" that more efficiently generates NMN.3 It increases NMN levels and prevents NAD+ feedback inhibition in a cell-free assay using recombinant human NAMPT at a concentration of 2 uM. In mice (20 mg/kg), it increases liver levels of NAD+ and shows a trend toward increased levels in cardiac tissue but does not affect levels in the quadriceps, or gastrocnemius.3
- Immunogen:
- Energy production
- Molecular Weight:
- 402.47
- Physical State:
- Solid
- Purity:
- >98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
