OSS-128167
Product Sizes
5 mg
£163.00
10-5197-5MG
25 mg
£281.00
10-5197-25MG
About this Product
- SKU:
- 10-5197
- CAS Number:
- 887686-02-4
- Extra Details:
- OSS-128167 (887686-02-4) is an inhibitor of SIRT6 (IC50=89 uM) showing selectivity over SIRT1 and SIRT2 (IC50s=1,578 and 751 uM, respectively).1 In diffuse large B-cell lymphoma cells which overexpress SIRT6, treatment with OSS-128167 resulted in higher rates of apoptosis, arrested cell cycle progression and augmented sensitivity to chemotherapy.2 It exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress in a streptozotocin-induced diabetic mouse model3 and delays peripheral nerve recovery after injury by suppressing migration, phagocytosis and M2-polarization of macrophages4. OSS-128167 promotes cell senescence and aging in myocardial H9c2 cells.5
- Immunogen:
- Protein deacetylase
- Molecular Weight:
- 366.66
- Physical State:
- Solid
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here
