DBIC
Product Sizes
5 mg
£173.00
10-5161-5MG
25 mg
£339.00
10-5161-25MG
About this Product
- SKU:
- 10-5161
- CAS Number:
- 487026-67-5
- Extra Details:
- Specifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system.1 A negative control compound, DBIC-neg2 (Cat # 10-5162) is also available.
- Immunogen:
- DNA|Methyltransferase|Nucleic acid methylation
- Molecular Weight:
- 296.29
- Physical State:
- Solid
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here
