Vacuolin-1
Product Sizes
5 mg
£187.00
10-5151-5MG
25 mg
£378.00
10-5151-25MG
About this Product
- SKU:
- 10-5151
- CAS Number:
- 351986-85-1
- Extra Details:
- Vacuolin-1 (351986-85-1) inhibits autophagy via inhibition of Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content and has no effect on other membrane-bound organelles.1 It has been shown to block endosome maturation by activating RAB5 which compromises the biogenesis and function of lysosomes including autophagosomal-lysosomal fusion and endosomal-lysosomal degradation.2 It potently inhibits migration, invasion and colony formation of cancer cells (which is linked to endosomal trafficking) and targets capping protein ZB Beta (CapZB Beta) in these processes.3 Inhibition of lysosomal maturation was shown to be due to potent inhibition of PIKfyve.4
- Immunogen:
- Kinase|Lysosome
- Molecular Weight:
- 577.43
- Physical State:
- Solid
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
