SX-682
Product Sizes
5 mg
£187.00
10-4925-5MG
25 mg
£320.00
10-4925-25MG
About this Product
- SKU:
- 10-4925
- CAS Number:
- 1648843-04-2
- Extra Details:
- SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM)1. It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer.2 It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy.3 SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.4,5
- Immunogen:
- GPCR
- Molecular Weight:
- 467.20
- Physical State:
- Solid
- Purity:
- 98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here
