Motolimod
Product Sizes
5 mg
£177.00
10-4920-5MG
25 mg
£334.00
10-4920-25MG
About this Product
- SKU:
- 10-4920
- Additional Names:
- VTX-2337
- CAS Number:
- 926927-61-9
- Extra Details:
- Motolimod (926927-61-9) is a selective Toll-like receptor 8 (TLR8) agonist (EC50 = 100 nM). It stimulates the production of TNFA Alpha and IL-12 from monocytes and myeloid dendritic cells. Motolimod also stimulated IFNG Gamma production from NK cells and increased their toxicity against K562 and ADCC by rituximab and trastuzumab.1,2 It induced apoptosis in monocytic myeloid-derived suppressor cells.3 Motolimod is being investigated in combination with other cancer immunotherapies.4,5 Motolimod has also been shown in induce secreted IL-1b and IL-8 via activation of the NLRP3 inflammasome.6
- Immunogen:
- Inflammasome|TLR (Toll-like receptor)
- Molecular Weight:
- 458.61
- Physical State:
- Solid
- Purity:
- 98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Sell Sheet 1:
- View Sell Sheet Here
