LY2090314
Product Sizes
5 mg
£182.00
10-4854-5MG
25 mg
£349.00
10-4854-25MG
About this Product
- SKU:
- 10-4854
- Additional Names:
- 3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6.7.1-hi]indol-7-yl)-4-(imidazo[1.2-a]pyridine-3-yl)-1H-pyrrole-2,5-dione
- CAS Number:
- 603288-22-8
- Extra Details:
- Wnt/B Beta-catenin pathway activator. LY2090314 is a highly potent (IC50 = 1.5 nM GSK-3A Alpha; 0.9 nM GSK-3B Beta) and selective inhibitor of glycogen synthase-3-kinase (GSK-3).1,2 It stabilized B Beta-catenin levels and elevated expression of Axin2 leading to tumor growth delays in A375 melanoma xenografts.2 LY2090314 significantly reduced growth in multiple neuroblastoma cell lines.3 It inhibited growth and induced apoptosis in osimertinib-resistant lung cancer cells, specifically those with a mesenchymal phenotype.4
- Immunogen:
- Kinase
- Molecular Weight:
- 512.54
- Physical State:
- Solid
- Purity:
- >98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here
