Salubrinal
Product Sizes
5 mg
£153.00
10-4517-5MG
25 mg
£229.00
10-4517-25MG
About this Product
- SKU:
- 10-4517
- CAS Number:
- 405060-95-9
- Extra Details:
- Endoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2A Alpha).1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2A Alpha resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3
- Immunogen:
- Phosphatase|UPR (Unfolded Protein Response)
- Molecular Weight:
- 479.81
- Physical State:
- Solid
- Purity:
- 98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here
- Sell Sheet 2:
- View Sell Sheet Here
- Sell Sheet 3:
- View Sell Sheet Here
