Crisdesalazine
Product Sizes
25 mg
£354.00
10-4416-25MG
5 mg
£354.00
10-4416-5MG
About this Product
- SKU:
- 10-4416
- Additional Names:
- AAD-2004
- CAS Number:
- 927685-43-6
- Extra Details:
- Crisdesalazine is a potent inhibitor of microsomal prostaglandin E2 synthase-1 (IC50 = 230 nM).1 It also acted as a potent spin-trapping molecule and completely removed free radical at 50 nM. Crisdesalazine displayed efficacy in mouse models of ALS1 and Alzheimer's disease2. In a mouse model of spinal cord injury, it inhibited proliferation of astrocytes via hydrogen peroxide inhibition and promoted nerve regeneration.3 It also significantly alleviated clinical symptoms in a mouse model of multiple sclerosis by promoting the M1 to M2 phase transition in macrophages.4 Crisdesalazine in combination with cisplatin restored CD8+ T cell function and significantly improved efficacy compared to cisplatin monotherapy in an ovarian cancer model.5
- Immunogen:
- GPCR
- Molecular Weight:
- 325.29
- Physical State:
- Solid
- Purity:
- >98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
