HD2
Product Sizes
5 mg
£173.00
10-4370-5MG
25 mg
£291.00
10-4370-25MG
About this Product
- SKU:
- 10-4370
- CAS Number:
- 2543578-57-8
- Extra Details:
- HD2 is a potent (IC50 = 2.96 nM) inhibitor of DCN1, an important co-E3 ligase of neddylation. Displays favorable pharmacokinetics and low toxicity (including no hepatotoxicity). Selective against other DCN family members as well as ACE. HD2 reduced the migration and proliferation of Ang II-treated cardiac fibroblasts. Active in an isoproterenol-induced pathological cardiac remodeling and fibrosis mouse model. HD2 is a promising new therapeutic option for treatment of cardiac remodeling and fibrosis.
- Immunogen:
- Neddylation
- Molecular Weight:
- 426.84
- Physical State:
- Solid
- Purity:
- >98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
