VT103
Product Sizes
5 mg
£206.00
10-4296-5MG
25 mg
£387.00
10-4296-25MG
About this Product
- SKU:
- 10-4296
- CAS Number:
- 2290608-13-6
- Extra Details:
- VT103 inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts the interaction between YAP/TAZ and TEAD via inhibition of TEAD1 (IC50 = 1 nM).1 It prevented TAC-induced cardiac hypertrophy and dysfunction in WT mice by blocking the interaction of TEAD1 with BRD4.2 VT103 enhanced the efficacy of dabrafenib in KTOR81 lung adenocarcinoma cells and xenograft models.3 VT103 acts a molecular glue between TEAD and the transcriptional repressor VGLL4 leading to antagonism of YAP activity.4
- Immunogen:
- Molecular glue|Transcription factor
- Molecular Weight:
- 410.42
- Physical State:
- Solid
- Purity:
- >98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
