Elesclomol
Product Sizes
5 mg
£158.00
10-4238-5MG
25 mg
£238.00
10-4238-25MG
About this Product
- SKU:
- 10-4238
- Additional Names:
- GSK842879A|STA-4783
- CAS Number:
- 488832-69-5
- Extra Details:
- Elesclomol induced oxidative stress in cancer cells via rapid generation of reactive oxygen species.1 It preferentially binds copper ions outside the cell and selectively transports inside the mitochondria with subsequent reactive oxygen species generation leading to apoptosis.2,3 Elesclomol can restore copper homeostasis in models of copper deficiency and disorders of copper metabolism.4,5 Copper-induced cell death (Cuproptosis) caused by Elesclomol is now believed to occur via direct binding of copper to lipoylated components of the tricarboxylic acid cycle causing protein aggregation and subsequent iron-sulfur protein loss leading to proteotoxic stress and cell death.6
- Immunogen:
- Chelator
- Molecular Weight:
- 400.52
- Physical State:
- Solid
- Purity:
- 98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
