Dynarrestin
Product Sizes
5 mg
£177.00
10-4196-5MG
25 mg
£325.00
10-4196-25MG
About this Product
- SKU:
- 10-4196
- Additional Names:
- LDC3
- CAS Number:
- 2222768-84-3
- Extra Details:
- Dynarrestin is a reversible inhibitor of cytoplasmic dyneins 1 and 2.1 It inhibits dynein 1-dependent microtubule binding and motility without affecting ATP hydrolysis as well as dynein 2-dependent intraflagellar transport of the cargo IFT88 and flux of Smoothened within cilia without interfering with ciliogenesis. Dynarrestin suppresses hedgehog-dependent proliferation of neuronal precursors and tumor cells. It binds protein tyrosine phosphatase interacting protein 51 (PTPIP51) leading to increased MAPK activation and complete blockade of Akt signaling in Her2 positive breast cancer cells (SKBR3).2
- Immunogen:
- Cytoskeleton
- Molecular Weight:
- 431.5
- Physical State:
- Pale pink/purple solid
- Purity:
- >98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here
