GSK3326595
Product Sizes
5 mg
£149.00
10-4028-5MG
25 mg
£238.00
10-4028-25MG
About this Product
- SKU:
- 10-4028
- Additional Names:
- EPZ015938
- CAS Number:
- 1616392-22-3
- Extra Details:
- GSK3326595 is a potent (IC50 = 6.2nM), selective (>4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5.1 PRMT5 inhibition activated the p53 pathway via induction of alternative splicing of MDM4 leading to a potent anti-proliferative response both in vitro and in vivo. Combination therapy with palbociclib (CDK4/6 inhibitor, Focus Cat.# 10-4760) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis.2 Currently in clinical Trials.3
- Immunogen:
- Protein methyltransferase|RNA
- Molecular Weight:
- 452.56
- Physical State:
- Solid
- Purity:
- 98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here
- Sell Sheet 2:
- View Sell Sheet Here
