Grapiprant
Product Sizes
5 mg
£177.00
10-4006-5MG
25 mg
£291.00
10-4006-25MG
About this Product
- SKU:
- 10-4006
- Additional Names:
- ARY-007|CJ-023,423
- CAS Number:
- 415903-37-6
- Extra Details:
- Grapiprant is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5
- Immunogen:
- GPCR
- Molecular Weight:
- 491.61
- Physical State:
- Solid
- Purity:
- 98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
