SP100030
Product Sizes
5 mg
£158.00
10-3996-5MG
25 mg
£267.00
10-3996-25MG
About this Product
- SKU:
- 10-3996
- Additional Names:
- 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'-bis(trifluoromethyl)phenyl)carboxamide
- CAS Number:
- 154563-54-9
- Extra Details:
- SP100030 is a potent dual inhibitor of NF-kB- and AP-1-mediated gene expression (IC50's = 50 nM for both in transfected Jurkat T-cells).1 It was able to specifically block IL-2 and IL-8 in Jurkat T-cells (IC50's = 30 nM for both).1 SP100030 treatment significantly decreased arthritis severity in DBA/1J mice.2 It selectively inhibited CD8(+) T-cells and mRNA expression of TH1 and Th2 cytokines in a rat model of asthma but did not inhibit allergen-induced eosinophilia and bronchial hyperresponsiveness.3 SP100030 ameliorated muscle wasting in a cancer cachexia rat model.4 SP100030 suppression of T cell activation has been attributed to targeting of XPO1 (with minimal impact on nuclear export and cell viability).5
- Immunogen:
- Transcription factor
- Molecular Weight:
- 437.65
- Physical State:
- Solid
- Purity:
- >98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
