YL-365
Product Sizes
5 mg
£177.00
10-3988-5MG
25 mg
£334.00
10-3988-25MG
About this Product
- SKU:
- 10-3988
- Additional Names:
- 1-[4-(3-Chlorophenyl)benzoyl]-4-[[2-(4-phenylmethoxyphenyl)acetyl]amino]piperidine-4-carboxylic acid
- Extra Details:
- YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and has been implicated in several types of cancer.2 YL-365 showed no activity against various other GPCRs as well as a panel of 378 kinases. It alleviated hyperalgesia in a mouse model of neuropathic pain via downregulation of iNOS in M1 microglia without any toxicity.
- Immunogen:
- GPCR
- Molecular Weight:
- 583.08
- Physical State:
- Solid
- Purity:
- >98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
