HRO761
Product Sizes
5 mg
£186.00
10-3981-5MG
25 mg
£363.00
10-3981-25MG
About this Product
- SKU:
- 10-3981
- CAS Number:
- 2869954-34-5
- Extra Details:
- HRO761 is a potent (IC50 = 9 nM), selective, non-covalent, and allosteric inhibitor of Werner syndrome RecQ helicase (WRN).1 It binds to the D1 and D2 helicase domain interface locking it into the inactive state. HRO761 selectively inhibits microsatellite instabile (MSI) cancer cells in vitro and in vivo via double-stranded DNA breaks, activation of the DDR, and induction of WRN degradation. It displayed synergistic effects with irinotecan in colorectal cancer cells.
- Immunogen:
- DNA
- Molecular Weight:
- 702.09
- Physical State:
- Solid
- Purity:
- >98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
