Ceapin-A7
Product Sizes
10 mg
£173.00
10-3974-10MG
50 mg
£334.00
10-3974-50MG
About this Product
- SKU:
- 10-3974
- CAS Number:
- 2323027-38-7
- Extra Details:
- Selective inhibitor (IC50 = 590 nM) of transcription factor ATF6A Alpha, one of the three branches of the unfolded protein response.1 It inhibits activation of ATF6A Alpha in response to ER stress without inhibiting ER-bound transcription factors ATF6B Beta or SREBP or the IRE1 or PERK branches of the UPR. Ceapin-A7 also show no toxicity to unstressed cells. It induces neomorphic association of the ER and peroxisomes by directly tethering the cytosolic domain of ATF6a to the peroxisomal transporter ABCD3 without inhibiting its transporter activity.2 See companion activator 10-3973.
- Immunogen:
- ER/Golgi|Transcription factor|UPR (Unfolded Protein Response)
- Molecular Weight:
- 470.33
- Physical State:
- Solid
- Purity:
- 98%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here
