IMR-1
Product Sizes
5 mg
£158.00
10-3601-5MG
25 mg
£281.00
10-3601-25MG
About this Product
- SKU:
- 10-3601
- CAS Number:
- 310456-65-6
- Extra Details:
- Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 M (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 M (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
- Immunogen:
- Transcription factor
- Molecular Weight:
- 353.41
- Physical State:
- Solid
- Purity:
- 98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
