Koningic acid
Product Sizes
200 ug
£197.00
10-3326-200UG
1 mg
£301.00
10-3326-1MG
About this Product
- SKU:
- 10-3326
- Additional Names:
- Avocettin|BRN5091359|Heptelidic acid
- CAS Number:
- 74310-84-2
- Extra Details:
- Koningic acid (KA) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1 Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety2, Ki = 1.1 uM for rabbit muscle GAPDH3. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion.4 Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.5
- Immunogen:
- Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)
- Molecular Weight:
- 280.32
- Physical State:
- Solid
- Purity:
- 95%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
