Ethacrynic acid
Product Sizes
1 g
£158.00
10-2826-1G
5 g
£281.00
10-2826-5G
About this Product
- SKU:
- 10-2826
- Additional Names:
- MK-595|NSC-85791
- CAS Number:
- 58-54-8
- Extra Details:
- Ethacrynic acid (58-54-8) was found to be an inhibitor of glutathione transferase P1-1 (GST P1-1) in a screen of FDA-approved drugs. It inhibits both GST P1-1 and A3-1, IC50s=4.9 and 0.4 uM respectively and apparently acts as an allosteric inhibitor.1 It forms conjugates with glutathione which also inhibit GST competitively.2 Ethacrynic acid is cytotoxic to a number of cancer cells3 and synergizes with anticancer agents like afatinib4. It is a clinically useful diuretic agent.5
- Immunogen:
- Glutathione
- Molecular Weight:
- 303.14
- Physical State:
- Solid
- Purity:
- >99%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
