Halofuginone HBr
Product Sizes
10 mg
£158.00
10-2381-10MG
50 mg
£235.00
10-2381-50MG
About this Product
- SKU:
- 10-2381
- Additional Names:
- NSC 713205
- CAS Number:
- 64924-67-0
- Extra Details:
- Potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-B Beta signaling, including reversibly reducing Smad3 protein levels and inhibiting fibroblast differentiation.2 Blocks fibrosis, angiogenesis, and tumor progression.2,3 Inhibition of PRS results in amino acid starvation which activates the integrated stress response (ISR) and mTOR signaling4 and thus preventing differentiation of TH17 cells, suppressing the autoimmune response5. Reduces TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation, limiting SARS-CoV-2 cellular entry.6
- Molecular Weight:
- 495.6
- Physical State:
- Solid
- Purity:
- >98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Sell Sheet 1:
- View Sell Sheet Here
- Sell Sheet 2:
- View Sell Sheet Here
