Irinotecan HCl
Product Sizes
50 mg
£158.00
10-2146-50MG
250 mg
£281.00
10-2146-250MG
About this Product
- SKU:
- 10-2146
- CAS Number:
- 136572-09-3
- Extra Details:
- Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
- Immunogen:
- DNA|Topoisomerase
- Molecular Weight:
- 586.69 ∙ 36.46 ∙ 54.05
- Physical State:
- Solid
- Purity:
- 98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
