CBR-5884
Product Sizes
5 mg
£182.00
10-1588-5MG
25 mg
£375.00
10-1588-25MG
About this Product
- SKU:
- 10-1588
- Extra Details:
- Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 uM1. The action of PHGDH is the first committed step of serine biosynthesis2 and certain cancer cells overexpress PHGDH3. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 uM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents1.
- Molecular Weight:
- 336.39
- Physical State:
- Solid
- Purity:
- 98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Inhibitors
- Manufacturer's Data Sheet:https://focusbiomolecules.com/cellular-metabolism/cbr-5884-phgdh-serine-biosynthesis-inhibitor/