XIB4035
Product Sizes
5 mg
£158.00
10-1486-5MG
25 mg
£281.00
10-1486-25MG
About this Product
- SKU:
- 10-1486
- CAS Number:
- 10023-54-8
- Extra Details:
- A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor A Alpha-1 GFRA Alpha-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 uM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRA Alpha family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson's disease therapeutics.4
- Molecular Weight:
- 750.45
- Physical State:
- Solid
- Purity:
- 98%
- Shipping Conditions:
- Ambient
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Sell Sheet 1:
- View Sell Sheet Here
