24(S)-Hydroxycholesterol
Product Sizes
1 mg
£182.00
10-1331-1MG
5 mg
£418.00
10-1331-5MG
About this Product
- SKU:
- 10-1331
- Extra Details:
- 24(S)-Hydroxycholesterol is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in neuroblastoma cells3, possibly via a necroptosis pathway4. 24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORA Alpha and RORG Gamma (Ki = 25 nM).5 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications.6,7 It was also able to reduce AB Beta production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.7
- Molecular Weight:
- 402.66
- Physical State:
- Solid
- Purity:
- 99%
- Purification:
- HPLC Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Manufacturer's Data Sheet:https://focusbiomolecules.com/cell-death/24s-hydroxycholesterol-endogenous-cholesterol-metabolite/