NPL4 rabbit pAb
Product Sizes
50UL
£ POA
ES9944-50UL
100UL
£ POA
ES9944-100UL
About this Product
- SKU:
- ES9944
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:Binds ubiquitinated proteins via its RanBP2-type zinc finger.;function:The ternary complex containing UFD1L; VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm; where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.;pathway:Protein degradation; proteasomal ubiquitin-dependent pathway.;similarity:Belongs to the NPL4 family.;similarity:Contains 1 RanBP2-type zinc finger.;subcellular location:Associated with the endoplasmic reticulum and nuclear.;subunit:Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.;tissue specificity:Expressed at highest levels in brain; heart; skeletal muscle; kidney and fetal liver.;
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 270-350
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
