MAML2 rabbit pAb
Product Sizes
50UL
£ POA
ES9783-50UL
100UL
£ POA
ES9783-100UL
About this Product
- SKU:
- ES9783
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich; and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus; and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1; Suppressor of Hairless; LAG-1 (CSL) with ICN; and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas; while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the p
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 10-90
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
