EIF3A rabbit pAb
Product Sizes
50UL
£ POA
ES9656-50UL
100UL
£ POA
ES9656-100UL
About this Product
- SKU:
- ES9656
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Component of the eukaryotic translation initiation factor 3 (eIF-3) complex; which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1; eIF-1A; eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.;mass spectrometry: PubMed:17322308;PTM:Phosphorylated. Phosphorylation is enhanced upon serum stimulation.;similarity:Belongs to the eIF-3 subunit A family.;similarity:Contains 1 PCI domain.;subunit:Interacts with EIF4G1 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex; which is composed of 13 subunits: EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A; EIF3B; EIF3G and EIF3I; module B is composed of EIF3F; EIF3H; and EIF3M; and module C is composed of EIF3C; EIF3D; EIF3E; EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B; thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR; leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
