HECW1 rabbit pAb
Product Sizes
50UL
£ POA
ES9625-50UL
100UL
£ POA
ES9625-100UL
About this Product
- SKU:
- ES9625
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1; SSR3 and mutant SOD1 that lead to motor neuron death in FALS.;pathway:Protein modification; protein ubiquitination.;similarity:Contains 1 C2 domain.;similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.;similarity:Contains 2 WW domains.;subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.;tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.;
- Immunogen:
- Synthesized peptide derived from part region of human protein. AA range: 1-67
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
