DHI2 rabbit pAb
Product Sizes
50UL
£ POA
ES9568-50UL
100UL
£ POA
ES9568-100UL
About this Product
- SKU:
- ES9568
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- hydroxysteroid 11-beta dehydrogenase 2(HSD11B2) Homo sapiens There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase; a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme; encoded by this gene; has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney; the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone; thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor; such as the placenta and testis; it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol; particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mine
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
