HJURP rabbit pAb
Product Sizes
50UL
£ POA
ES9142-50UL
100UL
£ POA
ES9142-100UL
About this Product
- SKU:
- ES9142
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Directly binds Holliday junctions.;sequence caution:Translated as Arg.;subcellular location:Localizes in centromeres during late telophase and early G1; when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase; nucleolus site being often related to storage.;subunit:Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes. Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN.;tissue specificity:According to PubMed:17256767 highly expressed in the thymus with lower levels in the placenta; small intestine; liver; skeletal muscle; and colon. According to PubMed:17823411 highly expressed in testis; and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples; compared with normal lung.;
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 80-160
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
