LATS1/2 (Phospho-Thr1079/1041) Rabbit pAb
Product Sizes
50UL
£ POA
ES8881-50UL
100UL
£ POA
ES8881-100UL
About this Product
- SKU:
- ES8881
- Additional Names:
- Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner; with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity; indicating a role as a negative regulator of CDC2/cyclin A. In addition; the C-terminal kinase domain binds to its own N-terminal region; suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas; ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen
- Immunogen:
- Synthesized phospho derived from human LATS1/2 (Phospho-Thr1079/1041)
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
