CD275 rabbit pAb
Product Sizes
50UL
£ POA
ES8796-50UL
100UL
£ POA
ES8796-100UL
About this Product
- SKU:
- ES8796
- Additional Names:
- ICOS ligand (B7 homolog 2;B7-H2;B7-like protein Gl50;B7-related protein 1;B7RP-1;CD antigen CD275)
- Application:
- Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- alternative products:Additional isoforms seem to exist;function:Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions; as well as in modulating the secondary immune response by co-stimulating memory T-cell function.;induction:Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes; while it is decreased in dendritic cells.;sequence caution:The sequence differs from that shown in position 300 onward for unknown reason.;sequence caution:Translation N-terminally shortened.;similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family.;similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.;similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.;tissue specificity:Isoform 1 is widely expressed (brain; heart; kidney; liver; lung; pancreas; placenta; skeletal muscle; bone marrow; colon; ovary; prostate; testis; lymph nodes; leukocytes; spleen; thymus and tonsil); while isoform 2 is detected only in lymph nodes; leukocytes and spleen. Expressed on activated monocytes and dendritic cells.;
- Immunogen:
- Synthetic peptide from human protein at AA range: 201-250
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
