CYFIP2 rabbit pAb
Product Sizes
50UL
£ POA
ES8500-50UL
100UL
£ POA
ES8500-100UL
About this Product
- SKU:
- ES8500
- Additional Names:
- Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).;function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.;induction:By p53.;RNA editing:Partially edited. Editing appears to be brain-specific.;similarity:Belongs to the CYFIP family.;subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.;subunit:Interacts with FMR1; FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2; CYFIP2; C3orf10/HSPC300; NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate; releasing activated WASF1. The complex can also be activated by NCK1.;
- Immunogen:
- Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
