ACAP1 (phospho Ser554) rabbit pAb
Product Sizes
50UL
£ POA
ES8095-50UL
100UL
£ POA
ES8095-100UL
About this Product
- SKU:
- ES8095
- Additional Names:
- ACAP1; CENTB1; KIAA0050; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:PH domain binds phospholipids including phosphatidic acid; phosphatidylinositol 3-phosphate; phosphatidylinositol 3;5-bisphosphate (PIP2) and phosphatidylinositol 3;4;5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.;enzyme regulation:GAP activity stimulated by phosphatidylinositol 4;5-bisphosphate (PIP2) and phosphatidic acid.;function:GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.;miscellaneous:Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes.;PTM:Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1; export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.;similarity:Contains 1 Arf-GAP domain.;similarity:Contains 1 BAR domain.;similarity:Contains 1 PH domain.;similarity:Contains 3 ANK repeats.;subunit:Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1.;tissue specificity:Highest level in lung and spleen. Low level in heart; kidney; liver and pancreas.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Centaurin-beta1 around the phosphorylation site of Ser554. AA range:520-569
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
