Fish rabbit pAb
Product Sizes
50UL
£ POA
ES8080-50UL
100UL
£ POA
ES8080-100UL
About this Product
- SKU:
- ES8080
- Additional Names:
- SH3PXD2A; FISH; KIAA0418; SH3MD1; TKS5; SH3 and PX domain-containing protein 2A; Adapter protein TKS5; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains
- Application:
- Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:The fifth SH3 domain mediates binding with ADAM12; ADAM15 and ADAM19.;domain:The PX domain is required for podosome localization; and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3;4-biphosphate (PtdIns(3;4)P2).;function:Required for podosome formation; degradation of the extracellular matrix; and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3;4-biphosphate (PtdIns(3;4)P2). In association with ADAM12; mediates the neurotoxic effect of beta-amyloid peptide.;PTM:Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction; resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage; probably by ATM or ATR.;similarity:Belongs to the SH3PXD2 family.;similarity:Contains 1 PX (phox homology) domain.;similarity:Contains 5 SH3 domains.;subcellular location:Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.;subunit:Interacts with ADAM12; ADAM15 and ADAM19.;tissue specificity:Found in several cancer cell lines; particularly invasive breast carcinomas and melanomas.;
- Immunogen:
- Synthesized peptide derived from the N-terminal region of human Fish.
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
