RIN1 rabbit pAb
Product Sizes
50UL
£ POA
ES8073-50UL
100UL
£ POA
ES8073-100UL
About this Product
- SKU:
- ES8073
- Additional Names:
- RIN1; Ras and Rab interactor 1; Ras inhibitor JC99; Ras interaction/interference protein 1
- Application:
- Western Blot, ELISA, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Ras effector protein; which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First; by competing with RAF1 protein for binding to activated Ras. Second; by enhancing signaling from ABL1 and ABL2; which regulate cytoskeletal remodeling. Third; by activating RAB5A; possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A; by exchanging bound GDP for free GTP; and facilitating Ras-activated receptor endocytosis.;PTM:Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylated on Ser-351 by PKD.;similarity:Belongs to the RIN (Ras interaction/interference) family.;similarity:Contains 1 Ras-associating domain.;similarity:Contains 1 SH2 domain.;similarity:Contains 1 VPS9 domain.;subcellular location:Some amount is membrane-associated.;subunit:Interacts with the GTP-bound form of Ras proteins (NRAS; HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB; YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.;tissue specificity:Expressed in all tissues examined with high levels in brain; placenta and pancreas.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human RIN1. AA range:655-704
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
