TAL1 (phospho Ser122) rabbit pAb
Product Sizes
50UL
£ POA
ES7342-50UL
100UL
£ POA
ES7342-100UL
About this Product
- SKU:
- ES7342
- Additional Names:
- TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- alternative products:The splicing pattern is cell-lineage dependent;disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.;domain:The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.;function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.;PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.;PTM:Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122; ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells; since it could not be observed in large vessel endothelial cells.;similarity:Contains 1 basic helix-loop-helix (bHLH) domain.;subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3; LDB1; TAL1 and TCF3.;tissue specificity:Leukemic stem cell.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human TAL-1 around the phosphorylation site of Ser122. AA range:96-145
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
