BRCA1 (phospho Ser1457) rabbit pAb
Product Sizes
50UL
£ POA
ES7269-50UL
100UL
£ POA
ES7269-100UL
About this Product
- SKU:
- ES7269
- Additional Names:
- BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability; and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors; DNA damage sensors; and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II; and through the C-terminal domain; also interacts with histone deacetylase complexes. This protein thus plays a role in transcription; DNA repair of double-stranded breaks; and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human BRCA1 around the phosphorylation site of Ser1457. AA range:1423-1472
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
