Endophilin I rabbit pAb
Product Sizes
50UL
£ POA
ES7184-50UL
100UL
£ POA
ES7184-100UL
About this Product
- SKU:
- ES7184
- Additional Names:
- SH3GL2; CNSA2; SH3D2A; Endophilin-A1; EEN-B1; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2
- Application:
- Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:An N-terminal amphipathic helix; the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.;function:Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.;miscellaneous:HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation.;similarity:Belongs to the endophilin family.;similarity:Contains 1 BAR domain.;similarity:Contains 1 SH3 domain.;subcellular location:Concentrated in presynaptic nerve terminals in neurons.;subunit:Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP.;tissue specificity:Brain; mostly in frontal cortex. Expressed at high level in fetal cerebellum.;
- Immunogen:
- Synthesized peptide derived from Endophilin I . at AA range: 30-110
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
