Presenilin 1 (phospho Ser357) rabbit pAb
Product Sizes
50UL
£ POA
ES6846-50UL
100UL
£ POA
ES6846-100UL
About this Product
- SKU:
- ES6846
- Additional Names:
- PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase; an enzyme that cleaves APP. Also; it is thought that the presenilins are involved in the cleavage of the Notch receptor; such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene; the full-length nature of only some have been determined. [provided by RefSeq; Aug 2008];
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human PSEN1 around the phosphorylation site of Ser357. AA range:323-372
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
