CEP55 (phospho Ser425) rabbit pAb
Product Sizes
50UL
£ POA
ES6712-50UL
100UL
£ POA
ES6712-100UL
About this Product
- SKU:
- ES6712
- Additional Names:
- CEP55; C10orf3; URCC6; Centrosomal protein of 55 kDa; Cep55; Up-regulated in colon cancer 6
- Application:
- Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- function:Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.;PTM:There is a hierachy of phosphorylation; where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis; prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites; Ser-425; Ser-428 and Ser-436; is required for protein function at the final stages of cell division to complete cytokinesis successfully.;subcellular location:Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole; whereas the majority localizes to the pericentriolar material. During mitosis; loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis.;subunit:Homodimer. Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1. Interacts with AKAP9; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding. Interacts with FAM125A; VPS37B; VPS37C and VPS28.;tissue specificity:Widely expressed; mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus; as well as in various cancer cell lines. Low levels in different parts of the digestive tract; bone marrow; lymph nodes; placenta; fetal heart and fetal spleen. Hardly detected in brain.;
- Immunogen:
- Synthesized phospho-peptide around the phosphorylation site of human CEP55 (phospho Ser425)
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
