MARCH1 rabbit pAb
Product Sizes
50UL
£ POA
ES6692-50UL
100UL
£ POA
ES6692-100UL
About this Product
- SKU:
- ES6692
- Additional Names:
- MARCH1; RNF171; E3 ubiquitin-protein ligase MARCH1; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; MARCH-I; RING finger protein 171
- Application:
- Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins; thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al.; 2004 [PubMed 14722266]; Thibodeau et al.; 2008 [PubMed 18389477]; De Gassart et al.; 2008 [PubMed 18305173]).[supplied by OMIM; Mar 2010];
- Immunogen:
- Synthesized peptide derived from the Internal region of human 40603.
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
