RIAM rabbit pAb
Product Sizes
50UL
£ POA
ES6660-50UL
100UL
£ POA
ES6660-100UL
About this Product
- SKU:
- ES6660
- Additional Names:
- APBB1IP; PREL1; RARP1; RIAM; Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; APBB1-interacting protein 1; Proline-rich EVH1 ligand 1; PREL-1; Proline-rich protein 73; Rap1-GTP-interacting adapter molecule; R
- Application:
- Western Blot, Immunohistochemistry
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:The two Pro-rich regions are required for the suppression of AP1 transcription activity.;function:Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.;induction:Induced by all-trans-retinoic acid.;similarity:Belongs to the MRL family.;similarity:Contains 1 PH domain.;similarity:Contains 1 Ras-associating domain.;subcellular location:Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions; and F-actin at the leading edge. At the membrane surface; associates; via the PH domain; preferentially with the inositol phosphates; PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases.;subunit:Interacts; through the N-terminal Pro-rich region; with the WW domain of APBB1. Interacts with RAP1A; PFN1; VASP and ENAH.;tissue specificity:Widely expressed with high expression in thymus; spleen; lymph node; bone marrow and peripheral leukocytes.;
- Immunogen:
- Synthesized peptide derived from RIAM . at AA range: 430-510
- Isotype:
- IgG
- Reactivities:
- Human, Rat, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
