PDHK1 (phospho Ser241) rabbit pAb
Product Sizes
50UL
£ POA
ES6555-50UL
100UL
£ POA
ES6555-100UL
About this Product
- SKU:
- ES6555
- Additional Names:
- PDPK1; PDK1; 3-phosphoinositide-dependent protein kinase 1; hPDK1
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.;function:Phosphorylates and activates not only PKB/AKT; but also PKA; PKC-zeta; RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.;PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241; leading to its own activation.;similarity:Belongs to the protein kinase superfamily.;similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.;similarity:Contains 1 PH domain.;similarity:Contains 1 protein kinase domain.;subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.;subunit:Interacts with TUSC4.;tissue specificity:Appears to be expressed ubiquitously.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human PDK1 around the phosphorylation site of Ser241. AA range:210-259
- Isotype:
- IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Supplier:
- ELK Biotechnology
- Type:
- Antibodies: Polyclonal Antibody
