PIASy rabbit pAb
Product Sizes
50UL
£ POA
ES6540-50UL
100UL
£ POA
ES6540-100UL
About this Product
- SKU:
- ES6540
- Additional Names:
- PIAS4; PIASG; E3 SUMO-protein ligase PIAS4; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma
- Application:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- domain:The LXXLL motif is a coregulator signature that is essential for transcriptional corepression.;function:Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase; stabilizing the interaction between UBE2I and the substrate; and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways; including the STAT pathway; the p53 pathway; the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling; represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.;pathway:Protein modification; protein sumoylation.;PTM:Sumoylated. Lys-35 is the main site of sumoylation. Sumoylation is required for TCF4 sumoylation and transcriptional activitation. Represses LEF1 transcriptional activity. SUMO1 is the preferred conjugate.;similarity:Belongs to the PIAS family.;similarity:Contains 1 SAP domain.;similarity:Contains 1 SP-RING-type zinc finger.;subcellular location:Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.;subunit:Interacts with AR; GATA2; LEF1; TP53 and STAT1 (IFNG-induced). Binds to AT-rich DNA sequences; known as matrix or scaffold attachment regions (MARs/SARs) (By similarity). Interacts with TICAM1. Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase.;tissue specificity:Highly expressed in testis and; at lower levels; in spleen; prostate; ovary; colon and peripheral blood leukocytes.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human PIAS4. AA range:451-500
- Isotype:
- IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Source:
- Rabbit
- Storage Conditions:
- -20[o]C
- Type:
- Antibodies: Polyclonal Antibody
